Dodo, Ayush, and Pinku make an ordinary trio of boys who've been best friends since they were 10. Years have passed and lives have changed but one thing hasn't; their age-old dream of doing a Goa trip. They reunite years later and decide to take a trip to Goa, but what follows is a sequence of very bad decisions taken by three very luckless boys and unintentionally hilarious situations that you wouldn't want to be a part of 'Madgaon Express' talks about and explores a never seen before Goa through the eyes of these naive characters stuck in some of the most nonsensical circumstances. Police, gangsters, drugs, yeh ho kya raha hai?